@article{oai:osaka-aoyama.repo.nii.ac.jp:00000167,
 author = {小畑, 俊男},
 journal = {大阪青山大学看護学ジャーナル, Nursing Journal of Osaka Aoyama University},
 month = {Mar},
 note = {The present study was examined that modulators of semicarbazide-sensitive amine oxidase (SSAO; EC 1.4.3.6.) might be present in the brain cytosol and looked for changes in SSAO modulatory activity in brain cytosol.An endogenous inhibitor of SSAO (ESI) was separated by gel filtration from 105,000 g supernate of thyroxine (T4)-treated rat brain cytosol.The inhibition by this inhibitor withSSAO activity for 1 µmol/L benzylamine was concentration dependent. The mode of inhibition was competitive with benzylamine. The molecular weight of this inhibitor was estimated to be 600-700 by gel filtration. The pI value of ESI was determined by isoelectric focusing (IEF)-gel electrophoresis to about 3.6. SSAO inhibition activity was much lower in the cytosol of thyroidectomized, non-T4-treated rats than T4-treated rats, suggesting that this inhibitor is induced by thyroid hormone. SSAO activity in rat brain might be regulated by the level of this inhibitor.The results indicate that this inhibitor in T4-treated rat brain cytosol and that the level of this inhibitor is regulated by thyroid hormone.},
 pages = {15--21},
 title = {Thyroid hormone-inducible semicarbazide-sensitive amine oxidase (SSAO) in rat brain cytosol},
 volume = {2},
 year = {2018},
 yomi = {オバタ, トシオ}
}